Benzphetamine

Base Information

• Chemical Name: Benzphetamine
• CAS No.: 5411-22-3
• Molecular Formula: C17H21 N . Cl H
• Molecular Weight: 275.821
• Hs Code.: 2921499090
• European Community (EC) Number: 226-489-2
• UNII: 0M3S43XK27
• DSSTox Substance ID: DTXSID4022656
• Nikkaji Number: J215.740C
• Wikipedia: Benzphetamine
• Wikidata: Q3322838
• NCI Thesaurus Code: C61647
• RXCUI: 1422
• Pharos Ligand ID: 3YK65VB2S2CN
• Metabolomics Workbench ID: 43141
• ChEMBL ID: CHEMBL3545985
• Mol file: 5411-22-3.mol

Synonyms:Benzfetamine;Benzphetamine;Didrex

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Chemical Property of Benzphetamine

Chemical Property:

• Vapor Pressure: 0.000129mmHg at 25°C
• Melting Point: 129-130°
• Boiling Point: 334.3°Cat760mmHg
• Flash Point: 141.5°C
• PSA: 3.24000
• Density: g/cm³
• LogP: 4.55160
• Storage Temp.: 2-8°C
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 239.167399674
• Heavy Atom Count: 18
• Complexity: 214

Purity/Quality:

Safty Information:

• Pictogram(s): T,F
• Hazard Codes: T,F
• Statements: 23/24/25-63-39/23/24/25-11
• Safety Statements: 22-36/37/39-45-36/37-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)N(C)CC2=CC=CC=C2
• Isomeric SMILES: C[C@@H](CC1=CC=CC=C1)N(C)CC2=CC=CC=C2
• Uses: The S-enantiomer of Benzphetamine (B209880). Controlled substance (stimulant). Anorexic.

Technology Process of Benzphetamine

There total 13 articles about Benzphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzphetamine (156-08-1) → benzfetamine hydrochloride (5411-22-3)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 10 - 30 ℃;

Reference yield: 95.0%

Methamphetamin (537-46-2) + benzyl chloride (100-44-7) → benzphetamine (156-08-1) + benzfetamine hydrochloride (5411-22-3) + S-methamphetamine hydrochloride (51-57-0,4298-16-2)

Guidance literature:

In water; toluene; at 70 - 120 ℃; for 8.16667h; Product distribution / selectivity;

Reference yield: 93.0%

benzyl chloride (100-44-7) + S-methamphetamine hydrochloride (51-57-0,4298-16-2) → benzfetamine hydrochloride (5411-22-3)

Guidance literature:

S-methamphetamine hydrochloride; With potassium carbonate; In water; at 20 ℃; for 0.5h; Large scale;

benzyl chloride; In water; at 70 - 75 ℃; for 10h; Large scale;

With hydrogenchloride; In ethyl acetate; at 5 - 30 ℃; for 10h; Large scale;

DOI:10.1021/op400313y

upstream raw materials:

benzphetamine

Methamphetamin

benzyl chloride

S-methamphetamine hydrochloride

Downstream raw materials:

benzphetamine

Refernces

• 1、 -. "Benzphetamine hydrochloride preparation method". Paragraph 0135; 0136; 0137; 0138; 0139; 0140; 0141. . Retrieved 2020/01/25.
• 2、 -. "PROCESS FOR PREPARATION OF BENZPHETAMINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS". Page/Page column 3. . Retrieved 2011/04/14.