Methamphetamine

Base Information

• Chemical Name: Methamphetamine
• CAS No.: 537-46-2
• Deprecated CAS: 139-47-9,1690-86-4,14611-50-8,45952-89-4,14611-50-8,1690-86-4,45952-89-4
• Molecular Formula: C10H15 N
• Molecular Weight: 149.236
• Hs Code.: 2921499090
• European Community (EC) Number: 208-668-7
• NSC Number: 25115
• UNII: 44RAL3456C
• DSSTox Substance ID: DTXSID8037128
• Nikkaji Number: J6.362B
• Wikipedia: Methamphetamine
• Wikidata: Q191924
• NCI Thesaurus Code: C61840
• RXCUI: 6816
• Pharos Ligand ID: MYD86PBPJS3F
• Metabolomics Workbench ID: 43571
• ChEMBL ID: CHEMBL1201201
• Mol file: 537-46-2.mol

Synonyms:Deoxyephedrine;Desoxyephedrine;Desoxyn;Hydrochloride, Methamphetamine;Madrine;Metamfetamine;Methamphetamine;Methamphetamine Hydrochloride;Methylamphetamine;N Methylamphetamine;N-Methylamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Methamphetamine

Chemical Property:

• Vapor Pressure: 0.147mmHg at 25°C
• Melting Point: 143°C (estimate)
• Refractive Index: 1.5105 (estimate)
• Boiling Point: 215.5°Cat760mmHg
• PKA: 10.38±0.10(Predicted)
• Flash Point: 86.8°C
• PSA: 12.03000
• Density: 0.907g/cm³
• LogP: 2.22790
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 149.120449483
• Heavy Atom Count: 11
• Complexity: 95

Purity/Quality:

Safty Information:

• Pictogram(s): A poison. Human systemic effects reported.
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)NC
• Isomeric SMILES: C[C@@H](CC1=CC=CC=C1)NC
• Recent ClinicalTrials: Effect of Methamphetamine on Residual Latent HIV Disease Study
• Recent NIPH Clinical Trials: Comparative study of methoxyphenamine in active and passive smoking

Technology Process of Methamphetamine

There total 56 articles about Methamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pseudoephedrine (90-82-4,7009-81-6,90-83-5,6912-63-6) → Methamphetamin (537-46-2)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; at -78 - -20 ℃; for 1h; Reagent/catalyst;

Reference yield: 87.17%

(S)-(+)-N-Acetyl-N-methylamphetamine (89617-55-0) → Methamphetamin (537-46-2)

Guidance literature:

(S)-(+)-N-Acetyl-N-methylamphetamine; With hydrogenchloride; In water; at 104 - 105 ℃; for 12h; Heating / reflux;

With sodium hydroxide; In water; Product distribution / selectivity;

Reference yield: 85.0%

(-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin (124919-00-2) → Methamphetamin (537-46-2)

Guidance literature:

With naphthalene; water; lithium; In tetrahydrofuran; 1.) -78 deg C, 6 h, 2.) -78 - 20 deg C, 3 h;

DOI:10.1021/jo00090a044

upstream raw materials:

methamphetamin

formaldehyd

dexamfetamine

ephedrine

Downstream raw materials:

2-[methyl-((S)-1-methyl-2-phenyl-ethyl)-amino]-ethanethiol

N-methyl-N-((S)-1-methyl-2-phenyl-ethyl)-Ξ-lactamide

N-methyl-N-((S)-1-methyl-2-phenyl-ethyl)-glycolamide

4-nitro-benzoic acid-[methyl-((S)-1-methyl-2-phenyl-ethyl)-amide]

Refernces

Chiral gas chromatography as a tool for investigations into illicitly manufactured methylamphetamine

10.1002/chir.20957

The study aims to develop a chiral gas chromatographic method for separating compounds involved in the EMDE synthesis of methylamphetamine, a widely abused stimulant drug. The chemicals involved include ephedrine, pseudoephedrine, chlorinated intermediates, and methylamphetamine, which are the primary compounds of interest in the synthesis process. The researchers used fluorinated acid anhydrides such as trifluoroacetic anhydride (TFAA), pentafluoropropanoic anhydride (PFPA), and heptafluorobutyric anhydride (HFBA) as chemical derivatization reagents to reduce the polarity and basicity of these compounds, thereby improving enantiomeric separations. The study focused on separating the enantiomers of these compounds using a 2,3-di-O-methyl-6-t-butyl silyl-b-cyclodextrin stationary phase (CHIRALDEXTM B-DM) in a gas chromatograph. The results showed that PFPA derivatization effectively separated the enantiomers of pseudoephedrine, methylamphetamine, and chlorinated intermediates within 40 minutes, while TFAA was used for ephedrine enantiomers. The study concludes that this method can help identify the source of starting materials and synthetic routes used in the illicit manufacture of methylamphetamine, particularly distinguishing the Emde route from other methods like Birch reduction and Nagai methods.