Fosenazide

Base Information

• Chemical Name: Fosenazide
• CAS No.: 16543-10-5
• Molecular Formula: C14H15 N2 O2 P
• Molecular Weight: 274.259
• Hs Code.: 2931900090
• UNII: 16C19Z7F4I
• DSSTox Substance ID: DTXSID1046188
• Nikkaji Number: J32.493K
• Wikidata: Q27251802
• NCI Thesaurus Code: C65758
• ChEMBL ID: CHEMBL1357989
• Mol file: 16543-10-5.mol

Synonyms:diphenylphosphinylacetic acid hydrazide;gidifen

Chemical Property of Fosenazide

Chemical Property:

• Vapor Pressure: 2.8E-09mmHg at 25°C
• Melting Point: 159-160 °C
• Boiling Point: 477.4°Cat760mmHg
• PKA: 12.17±0.35(Predicted)
• Flash Point: 242.5°C
• PSA: 85.49000
• Density: 1.26g/cm³
• LogP: 2.53100
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 274.08711472
• Heavy Atom Count: 19
• Complexity: 325

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=O)(CC(=O)NN)C2=CC=CC=C2

Technology Process of Fosenazide

There total 5 articles about Fosenazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(diphenylphosphoryl)acetate (6361-05-3) → (diphenylphosphoryl)acetic acid hydrazide (16543-10-5)

Guidance literature:

With hydrazine hydrate; at 120 - 130 ℃;

Reference yield:

β-chloroethyl diphenylphosphite (35411-11-1) → (diphenylphosphoryl)acetic acid hydrazide (16543-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 4 h / 90 - 120 °C

2: NH₂NH₂ hydrate / 40 - 60 °C

With hydrazine hydrate; In dichloromethane;

Reference yield:

chloro-diphenylphosphine (1079-66-9,74391-44-9) → (diphenylphosphoryl)acetic acid hydrazide (16543-10-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) -5 - 5deg C, 2.) room temp.

2: CH₂Cl₂ / 4 h / 90 - 120 °C

3: NH₂NH₂ hydrate / 40 - 60 °C

With hydrazine hydrate; In dichloromethane;

upstream raw materials:

ethyl 2-(diphenylphosphoryl)acetate

oxirane

chloroacetic acid ethyl ester

chloro-diphenylphosphine

Downstream raw materials:

diphenylphosphinoacetyl azide

Diphenylphosphinylessigsaeure-isopropylidenhydrazid

Diphenylphosphinylessigsaeure-sec.-butylidenhydrazid

(Diphenyl-phosphinoyl)-acetic acid [1-thiophen-2-yl-meth-(E)-ylidene]-hydrazide