5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

Base Information

Chemical Name:5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole
CAS No.:1103501-11-6
Molecular Formula:C₁₈H₂₀Cl₂N₂O₂
Molecular Weight:367.275
Hs Code.:

Synonyms:5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

Suppliers and Price of 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

There total 9 articles about 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1296211-56-7
4-[5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester

: 1103501-11-6
5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

Guidance literature:: 4-[5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 25185-95-9
2,6-dichlorobenzaldoxime

: 1103501-11-6
5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 40 °C / Large scale

2.1: triethylamine / 0.5 h / 20 °C / Large scale

2.2: 10 - 20 °C / Large scale

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

5.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 - 20 °C

5.2: 14 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice

With N-chloro-succinimide; 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; diisobutylaluminium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.5b01161

Reference yield:

: 946426-88-6
5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-carboxylic acid methyl ester

: 1103501-11-6
5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

3.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 - 20 °C

3.2: 14 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice

With 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.5b01161