1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide
• CAS No.: 1598427-92-9
• Molecular Formula: C₂₆H₂₆N₄O₆
• Molecular Weight: 490.516
• Mol file: 1598427-92-9.mol

Synonyms:1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide

Chemical Property of 1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide

There total 4 articles about 1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.98%

4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one (893777-38-3) + 4-methoxy-aniline (104-94-9) → 1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide (1598427-92-9)

Guidance literature:

With sodium acetate; In acetic acid; for 2h; Reflux;

DOI:10.1016/j.ejmech.2014.03.001

Reference yield:

2-(3,4,5-trimethoxy-phenyl)-4H-oxazol-5-one (36974-48-8) → 1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide (1598427-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 2 h / 0 - 10 °C

2.1: sodium acetate / acetic acid / 2 h / Reflux

With hydrogenchloride; sodium acetate; sodium nitrite; In water; acetic acid;

DOI:10.1016/j.ejmech.2014.03.001

Reference yield:

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → 1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide (1598427-92-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide

2.1: acetic anhydride / Heating

3.1: sodium nitrite; hydrogenchloride / water / 0.17 h / -5 - 0 °C

3.2: 2 h / 0 - 10 °C

4.1: sodium acetate / acetic acid / 2 h / Reflux

With hydrogenchloride; sodium acetate; acetic anhydride; sodium hydroxide; sodium nitrite; In water; acetic acid;

DOI:10.1016/j.ejmech.2014.03.001

upstream raw materials:

2-(3,4,5-trimethoxy-phenyl)-4H-oxazol-5-one

4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one

4-methoxy-aniline

3,4,5-Trimethoxybenzoyl chloride