4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one

Base Information

• Chemical Name: 4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one
• CAS No.: 893777-38-3
• Molecular Formula: C₁₉H₁₉N₃O₆
• Molecular Weight: 385.376
• Mol file: 893777-38-3.mol

Synonyms:4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one

Chemical Property of 4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one

There total 3 articles about 4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4,5-trimethoxy-phenyl)-4H-oxazol-5-one (36974-48-8) + 4-methoxy-aniline (104-94-9) → 4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one (893777-38-3)

Guidance literature:

4-methoxy-aniline; With hydrogenchloride; sodium nitrite; In water; at -5 - 0 ℃; for 0.166667h;

2-(3,4,5-trimethoxy-phenyl)-4H-oxazol-5-one; With sodium acetate; In water; at 0 - 10 ℃; for 2h;

DOI:10.1016/j.ejmech.2014.03.001

Reference yield:

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → 4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one (893777-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide

2.1: acetic anhydride / Heating

3.1: sodium nitrite; hydrogenchloride / water / 0.17 h / -5 - 0 °C

3.2: 2 h / 0 - 10 °C

With hydrogenchloride; acetic anhydride; sodium hydroxide; sodium nitrite; In water;

DOI:10.1016/j.ejmech.2014.03.001

Reference yield:

(3,4,5-trimethoxybenzoylamino)acetic acid (40915-27-3) → 4-[(4-methoxyphenyl)hydrazono]-2-(3,4,5-trimethoxyphenyl)-4H-oxazol-5-one (893777-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride / Heating

2.1: sodium nitrite; hydrogenchloride / water / 0.17 h / -5 - 0 °C

2.2: 2 h / 0 - 10 °C

With hydrogenchloride; acetic anhydride; sodium nitrite; In water;

DOI:10.1016/j.ejmech.2014.03.001

upstream raw materials:

2-(3,4,5-trimethoxy-phenyl)-4H-oxazol-5-one

4-methoxy-aniline

3,4,5-Trimethoxybenzoyl chloride

(3,4,5-trimethoxybenzoylamino)acetic acid

Downstream raw materials:

1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid methylamide

1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid ethylamide

1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methoxyphenyl)amide

1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-[1,2,4]triazole-3-carboxylic acid (2-methoxyphenyl)amide