6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate

Base Information

Chemical Name:6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate
CAS No.:1434004-27-9
Molecular Formula:C₃₂H₃₅N₃O₅
Molecular Weight:541.647
Hs Code.:

Synonyms:6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate

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Chemical Property of 6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate

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Technology Process of 6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate

There total 4 articles about 6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1434004-06-4
6-ethyl 1-methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

: 100-39-0
benzyl bromide

: 1434004-27-9
6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate

Guidance literature:: 6-ethyl 1-methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1039/c3ob40223a

Reference yield:

: 1434003-91-4
ethyl 3-azido-4-ethynylbenzoate

: 1434004-27-9
6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: silver trifluoromethanesulfonate; [AuCl(IPr)] / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

2.1: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With rhodium(III) chloride hydrate; [AuCl(IPr)]; silver trifluoromethanesulfonate; sodium hydride; In 1,2-dimethoxyethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob40223a

Reference yield:

: 1434003-95-8
methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-isopropyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

: 1434004-27-9
6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With rhodium(III) chloride hydrate; sodium hydride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob40223a