2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione
• CAS No.: 1296137-14-8
• Molecular Formula: C₂₄H₂₆N₂O₃
• Molecular Weight: 390.482
• Mol file: 1296137-14-8.mol

Synonyms:2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione

There total 7 articles about 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

phthalimide (136918-14-4,85-41-6) + C16H23NO2 (1041756-51-7) → 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione (1296137-14-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/hlca.201100415

Reference yield: 87.0%

C17H25NO4S (1296137-13-7) + potassium phtalimide (1074-82-4) → 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione (1296137-14-8)

Guidance literature:

In N,N-dimethyl-formamide; at 50 ℃; for 8h;

DOI:10.1016/j.ejmech.2011.01.034

Reference yield:

γ-(4-piperidyl)butyric acid hydrochloride → 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione (1296137-14-8)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 2 h / 20 °C

2: pyridine / dichloromethane / 3 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

4: triethylamine / dichloromethane / 2 h / 20 °C

5: N,N-dimethyl-formamide / 8 h / 50 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.01.034

upstream raw materials:

4-piperidin-4-ylbutyric acid methyl ester

methyl 4-(1-benzoylpiperidin-4-yl)butanoate

C₁₆H₂₃NO₂

C₁₇H₂₅NO₄S

Downstream raw materials:

[4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone

(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(3-nitrophenyl)acrylamide

(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-pyrrol-2-yl)acrylamide

(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-pyrazol-4-yl)acrylamide