[4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone

Base Information

• Chemical Name: [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone
• CAS No.: 1041756-57-3
• Molecular Formula: C₁₆H₂₄N₂O
• Molecular Weight: 260.379
• Mol file: 1041756-57-3.mol

Synonyms:[4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone

Chemical Property of [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone

There total 12 articles about [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4-(4-azidobutyl)piperidin-1-yl)(phenyl)methanone → [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone (1041756-57-3)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; Reflux;

Reference yield: 92.0%

2-(4-(piperidin-4-yl)butyl)isoindoline-1,3-dione hydrochloride + benzoyl chloride (98-88-4) → [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone (1041756-57-3)

Guidance literature:

2-(4-(piperidin-4-yl)butyl)isoindoline-1,3-dione hydrochloride; benzoyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

With hydrazine hydrate; In ethanol; for 2h; Inert atmosphere; Reflux;

Reference yield: 70.0%

2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione (1296137-14-8) → [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone (1041756-57-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 2.16667h; Inert atmosphere; Reflux;

DOI:10.1002/hlca.201100415

upstream raw materials:

4-piperidin-4-ylbutyric acid methyl ester

methyl 4-(1-benzoylpiperidin-4-yl)butanoate

C₁₆H₂₃NO₂

C₁₇H₂₅NO₄S

Downstream raw materials:

(E)-N-[4-(1-benzoyl-4-piperidinyl)butyl]-2-(3-pyridinyl)-1-ethenesulfonamide

(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-pyrrol-2-yl)acrylamide

(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-pyrazol-4-yl)acrylamide

(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-imidazol-4-yl)acrylamide