5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine
• CAS No.: 1025783-23-6
• Molecular Formula: C₃₈H₄₂N₆O₉
• Molecular Weight: 726.786

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine (1025783-29-2) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine (1025783-23-6)

Guidance literature:

With pyridine; at 20 ℃; for 18h;

DOI:10.1021/jm701537z

Reference yield: 71.0%

succinic acid anhydride (108-30-5) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine (1025783-23-6) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine 3'-O-succinate (1025783-30-5)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 4h;

DOI:10.1021/jm701537z

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine (1025783-23-6) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → [5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite (1025783-22-5)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1021/jm701537z

upstream raw materials:

2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine 3'-O-succinate

[5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-2-N-isobutyrylguanosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

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