2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester

Base Information

Chemical Name:2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester
CAS No.:1403378-36-8
Molecular Formula:C₂₂H₂₉N₃O₄S
Molecular Weight:431.556
Hs Code.:

Synonyms:2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester

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Chemical Property of 2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester

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Technology Process of 2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester

There total 6 articles about 2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.3%

: 96-50-4
2-thiazolylamine

: 1403378-82-4
2-methyl-2-(4-cyclopentylmethylaminophenoxy)propanoic acid ethyl ester

: 530-62-1
1,1'-carbonyldiimidazole

: 1403378-36-8
2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester

Guidance literature:: 2-thiazolylamine; 1,1'-carbonyldiimidazole; With dmap; In dichloromethane; for 48h; Reflux;

2-methyl-2-(4-cyclopentylmethylaminophenoxy)propanoic acid ethyl ester; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 1403378-82-4
2-methyl-2-(4-cyclopentylmethylaminophenoxy)propanoic acid ethyl ester

: C₇H₈N₄OS

: 1403378-36-8
2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2014.02.024

Reference yield:

: 23501-39-5
ethyl 2‐methyl‐2‐(4‐nitrophenoxy)propanoate

: 1403378-36-8
2-methyl-2-(4-(1-cyclopentylmethyl-3-(thiazol-2-yl)ureido)phenoxy)propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / methanol / 8 h / 20 °C / 760.05 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: dichloromethane / 12 h / 0 - 20 °C

With hydrogen; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.02.024