4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline

Base Information

Chemical Name:4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline
CAS No.:1445860-67-2
Molecular Formula:C₂₃H₂₄ClFN₄O₃
Molecular Weight:458.92
Hs Code.:

Synonyms:4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline

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Chemical Property of 4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline

Chemical Property:

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Technology Process of 4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline

There total 15 articles about 4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1445860-67-2
4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 2 h / 90 °C

2: ammonia; methanol / 12 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

With methanol; ammonia; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 912556-91-3
6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine

: 174-78-7
2-oxa-6-azaspiro[3.3]heptane

: 1445860-67-2
4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 4h;

Reference yield:

: 13794-72-4
3H-6,7-dimethoxyquinazolin-4-one

: 1445860-67-2
4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 7 steps

1: methanesulfonic acid; DL-methionine / 12 h / 120 °C

2: dmap; pyridine / 12 h / 0 - 20 °C

3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 14 h / 120 °C

4: isopropyl alcohol / 2 h / 90 °C

5: ammonia; methanol / 12 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

7: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

With pyridine; methanol; dmap; methanesulfonic acid; ammonia; potassium carbonate; N-ethyl-N,N-diisopropylamine; DL-methionine; trichlorophosphate; In N,N-dimethyl-formamide; isopropyl alcohol; toluene;