174-78-7

Basic information

• Product Name: 2-oxa-6-azaspiro[3.3]heptane
• Synonyms: 2-oxa-6-azaspiro[3.3]heptane;2-Oxa-6-aza-spiro[3.3]heptane oxalic acid salt;2-oxa-6-azaspiro[3,3]heptanes oxalic acid salt;2-oxa-6-azaspiro[3.3]heptanes (ForM: oxalate);2-oxa-6-azaspiro[3.3]heptanes oxalate;2-OXA-6-AZASPIRO[3.3]HEPTANE HCL
• CAS NO: 174-78-7
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.1321
• Mol File: 174-78-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 166℃
• Flash Point: 51℃
• Appearance: /
• Density: 1.12
• Vapor Pressure: 1.85mmHg at 25°C
• Refractive Index: 1.4750 to 1.4790
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.73±0.20(Predicted)
• CAS DataBase Reference: 2-oxa-6-azaspiro[3.3]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxa-6-azaspiro[3.3]heptane(174-78-7)
• EPA Substance Registry System: 2-oxa-6-azaspiro[3.3]heptane(174-78-7)

Safety Data

• RIDADR: UN 1993 3/PG III
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 174-78-7(Hazardous Substances Data)

Usage

General Description

2-Oxa-6-azaspiro[3.3]heptane is a chemical compound with the molecular formula C6H11NO. It is a heterocyclic compound that contains a spiro ring system, with an oxygen and nitrogen atom in the ring. 2-Oxa-6-azaspiro[3.3]heptane has potential pharmaceutical applications and may be used as a building block in the synthesis of other organic compounds. Its unique structure and functional groups make it a valuable starting material for the production of various types of drugs and biologically active compounds. The spiro ring system and the presence of oxygen and nitrogen atoms make 2-Oxa-6-azaspiro[3.3]heptane an interesting and important molecule for chemical and pharmaceutical research.

InChI:InChI=1/C5H9NO/c1-5(2-6-1)3-7-4-5/h6H,1-4H2

Upstream product

• 13573-28-9 6-(p-toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane 
• 2402-83-7 3,3-bis(bromomethyl)oxetane 
• 78-71-7 3,3-bis(chloromethyl)oxetane 
• 1522-92-5 2,2-bis(bromomethyl)-3-bromo-propan-1-ol 
• 46246-91-7 2-benzyl-6-oxa-2-azaspiro[3.3]-heptane 

Downstream Products

• 1045709-32-7 bis(2-oxa-6-azaspiro[3.3]heptan-6-ium) ethanedioate 
• 1420890-70-5 C₂₁H₂₄ClN₇O₂ 
• 1439358-11-8 C₁₈H₂₀N₄O₄S 
• 1258444-30-2 (1R,2R,4R)-4-(benzenesulfonyl)-N-(1-cyanocyclopropyl)-2-({2-oxa-6-azaspiro[3.3]heptan-6-yl}carbonyl)cyclopentane-1-carboxamide 
• 1575815-70-1 N-(5-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)-2-methylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)-6,7-dihydro-5H-pyrano[2,3-d]pyrimidin-2-yl)amino)benzamide 
• 1595286-02-4 (E)-N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)but-2-enamide 
• 1159599-99-1 2-oxa-6-azaspiro[3.3]heptan-6-ium carboxyformate 
• 1449279-92-8 tert-butyl (1S,2R)-2-hydroxy-3-oxo-1-phenyl-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-propylcarbamate 
• 1449279-91-7 N-((1S,2R)-2-hydroxy-3-oxo-1-phenyl-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)propyl)-benzamide 
• 1449279-90-6 (4S,5R)-tert-butyl-2-(4-methoxyphenyl)-4-phenyl-5-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)oxazolidine-3-carboxylate 
• 1449279-89-3 (4S,5R)-(3-benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidin-5-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone 
• 1445860-67-2 4-(3'-chloro-4'-fluorophenylamino)-6-[3-(2-oxa-6-azaspiro[3.3]heptane-6-yl)propoxy]-7-methoxyquinazoline 
• 1445861-29-9 4-(3'-chloro-4'-fluorophenylamino)-6-[2-(2-oxa-6-azaspiro[3.3]heptane-6-yl)oxethyl]-7-methoxyquinazoline 
• 1361218-86-1 1,1,1-trifluoro-2-(4-((2S)-2-(2-oxa-6-azaspiro[3.3]hept-6-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol 

Relevant articles and documents

SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY

The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

The Development of a Manufacturing Route to an MCHr1 Antagonist

Process development work to provide an efficient manufacturing route to a MCHr1 antagonist is presented herewith. Features of this development work include a scalable manufacturing route to the useful 6-oxa-2-azaspiro[3.3]heptane building block and the use of a (soluble) alternative to sodium triacetoxyborohydride.

Design, synthesis and biological evaluation of paclitaxel-mimics possessing only the oxetane D-ring and side chain structures

Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure-activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than paclitaxel, but which still represented the first example of simplified paclitaxel analogues with significant anti-tumor biological activity.