cyclo

Base Information

Chemical Name:cyclo
CAS No.:104849-04-9
Molecular Formula:C₃₀H₄₄N₄O₆
Molecular Weight:556.703
Hs Code.:

cyclo<L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-α-aminoisobutyryl-L-phenylalanyl-D-prolyl>

Synonyms:cyclo

Suppliers and Price of cyclo

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclo

Chemical Property:

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Technology Process of cyclo

There total 4 articles about cyclo which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 104849-03-8
L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-α-aminoisobutyryl-L-phenylalanyl-D-proline acetate salt

: 104849-04-9
cyclo

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at -10 - 20 ℃; for 64h;
DOI:10.1021/jm00384a013

Reference yield:

: 49645-27-4
(S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid

: 104849-04-9
cyclo

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ) / ethyl acetate / 27 h / 0 - 20 °C

2: 96 percent / 1.0 N aq. NaOH / methanol / Ambient temperature

3: 94 percent / H₂ / 10percent Pd/C / methanol / 3 h

4: 24 percent / Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) / CH₂Cl₂ / 64 h / -10 - 20 °C

With sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00384a013

Reference yield:

: 104874-88-6
N-(benzyloxycarbonyl)-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-α-aminoisobutyryl-L-phenylalanyl-D-proline methyl ester

: 104849-04-9
cyclo

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 1.0 N aq. NaOH / methanol / Ambient temperature

2: 94 percent / H₂ / 10percent Pd/C / methanol / 3 h

3: 24 percent / Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) / CH₂Cl₂ / 64 h / -10 - 20 °C

With sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00384a013