ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate

Base Information

Chemical Name:ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate
CAS No.:1428548-12-2
Molecular Formula:C₂₄H₂₄N₄O₅
Molecular Weight:448.478
Hs Code.:

Synonyms:ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate

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Chemical Property of ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate

Chemical Property:

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Technology Process of ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate

There total 6 articles about ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924-73-2
3-amino-propionic acid ethyl ester

: 1428548-45-1
5-(benzhydrylcarbamoyl)-4-hydroxypyrimidine-2-carboxylic acid

: 1428548-12-2
ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 1428548-40-6
ethyl 2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylate

: 1428548-12-2
ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate

Guidance literature:: Multi-step reaction with 6 steps

1: water; potassium hydroxide / 1 h / 70 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: palladium on activated charcoal; ammonium formate / methanol / Reflux

4: Dess-Martin periodane / dichloromethane / 20 °C

5: sodium chlorite; sodium hydrogenphosphate dodecahydrate / water; tert-butyl alcohol / 20 °C

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; palladium on activated charcoal; water; ammonium formate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1428548-43-9
N-benzhydryl-4-hydroxy-2-(hydroxymethyl)pyrimidine-5-carboxamide

: 1428548-12-2
ethyl N-({5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}carbonyl)-β-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: sodium chlorite; sodium hydrogenphosphate dodecahydrate / water; tert-butyl alcohol / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;