1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester
CAS No.:144514-24-9
Molecular Formula:C₁₉H₁₁F₄NO₃S
Molecular Weight:409.361
Hs Code.:

Synonyms:1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester

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Chemical Property of 1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester

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Technology Process of 1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester

There total 7 articles about 1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 84339-06-0
ethyl 7,6-difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylate

: 1-Dibromomethyl-2,4-difluoro-benzene

: 144514-24-9
1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 105 - 110 ℃; for 0.5h;
DOI:10.1021/jm00103a011

Reference yield:

: 113028-75-4
3,4-difluorophenyl isothiocyanate

: 144514-24-9
1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h

2: dimethylformamide / 1.) 0 deg C, 1.5 h, 2.) RT, 2 h

3: 58 percent / diphenyl ether / 5 h / 240 °C

4: 99 percent / 35percent HCl / ethanol / 2 h / Ambient temperature

5: 87 percent / K₂CO₃, KI / dimethylformamide / 0.5 h / 105 - 110 °C

With hydrogenchloride; potassium hydroxide; potassium carbonate; potassium iodide; In diphenylether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00103a011

Reference yield:

: 144514-15-8
3,4-difluorophenyl dithiocarbamic acid triethylammonium

: 144514-24-9
1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: ethyl chloroformate, triethylamine / CHCl₃ / 3.5 h / Ambient temperature

2: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h

3: dimethylformamide / 1.) 0 deg C, 1.5 h, 2.) RT, 2 h

4: 58 percent / diphenyl ether / 5 h / 240 °C

5: 99 percent / 35percent HCl / ethanol / 2 h / Ambient temperature

6: 87 percent / K₂CO₃, KI / dimethylformamide / 0.5 h / 105 - 110 °C

With hydrogenchloride; potassium hydroxide; chloroformic acid ethyl ester; potassium carbonate; triethylamine; potassium iodide; In diphenylether; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00103a011