84339-06-0

Basic information

• Product Name: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester
• Synonyms: Ethyl6,7-difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylate
• CAS NO: 84339-06-0
• Molecular Formula: C₁₂H₉F₂NO₃S
• Molecular Weight: 285.27
• Mol File: 84339-06-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester(84339-06-0)
• EPA Substance Registry System: 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester(84339-06-0)

Safety Data

• Hazardous Substances Data: 84339-06-0(Hazardous Substances Data)

Upstream product

• 150454-48-1 sodium salt of diethyl 3,4-difluorophenylamino(mercapto)methylenemalonate 
• 113028-76-5 diethyl<<(3,4-difluorophenyl)amino><(methoxymethyl)-thio>methylene>malonate 
• 144514-15-8 3,4-difluorophenyl dithiocarbamic acid triethylammonium 
• 113028-75-4 3,4-difluorophenyl isothiocyanate 
• 155106-45-9 4,5-Difluoro-2-methylsulfanylthiocarbonylamino-benzoic acid 
• 155106-46-0 6,7-difluoro-2-(methylthio)-4H-3,1-benzothiazin-4-one 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 155106-44-8 ethyl 3-(4,5-difluoro-2-{[(methylthio)carbonothioyl]amino}phenyl)-3-oxopropanoate 
• 113028-77-6 ethyl 6,7-difluoro-4-hydroxy-2-<(methoxymethyl)thio>-quinoline-3-carboxylate 
• 87238-78-6 ethyl 6,7-difluoro-4-hydroxy-2-(p-methoxybenzylthio)quinoline-3-carboxylate 
• 150454-50-5 diethyl 3,4-difluorophenylamino(p-methoxybenzylthio)methylenemalonate 
• 3863-11-4 3,4-difluoroaniline 

Downstream Products

• 144514-22-7 6,7-Difluoro-1-(4-fluoro-phenyl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 112984-60-8 ulifloxacin 
• 113028-17-4 ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113046-49-4 6-Fluoro-4-oxo-1-phenyl-7-(1-piperazinyl)-4H-[1,3]-thiazeto-[3,2-a]quinoline-3-carboxylic acid 
• 113045-95-7 ethyl 6-fluoro-4-oxo-1-phenyl-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113045-94-6 ethyl 6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1-phenyl-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113046-68-7 6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 113028-65-2 6-Fluoro-1-(2-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 123447-62-1 prulifloxacin 
• 113046-60-9 1-(2,4-Difluoro-phenyl)-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 84339-10-6 7-fluoro-1-methyl-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid 
• 84339-08-2 7-fluoro-1-methyl-5-oxo-8-(1-piperazinyl)-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid 
• 144514-21-6 6,7-Difluoro-4-oxo-1-phenyl-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 113046-72-3 ethyl 6,7-difluoro-1-methyl-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 

Relevant articles and documents

Synthesis and antibacterial activity of novel 7-substituted-6-fluoro-1- fluoromethyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives

A series of 7-substituted-6-fluoro-1-fluoromethyl-4-oxo-4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives (2a - I) was prepared and evaluated for antibacterial activity. These compounds were obtained by deacylation of 4-benzoyloxy-2-(1-chloro-2-fluoroethyl)thio-6,7- difluoroquinoline-3-carboxylate (10) and subsequent intramolecular cyclization followed by substitution with cyclic amines and then hydrolysis. The intramolecular cyclization reaction of 18, one of the diastereomers (17, 18) revealed that the cyclization reaction proceeded through an inversion to afford (-)-11a in good chemical and optical yield. The enantiomers of 2a were prepared from the enantiomers of 11a, which were obtained by the optical resolution of the racemate using high-performance liquid chromatography (HPLC). Compounds 2a,b showed excellent in vitro and in vivo antibacterial activity against both gram-negative and gram-positive bacteria including quinolone and Methicillin-resistant Staphylococcus aureus.

7[4-(5 methyl-2-oxo-1,3-dioxalen-4-yl)methyl 1-piperzinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids

Quinolinecarboxylic acid derivatives of the formula (I) STR1 and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, straight or branch chain lower alkyl or phenyl unsubstituted or substituted by one or more halo moieties; R

Studies on pyridonecarboxylic acids. 2. Synthesis and antibacterial activity of 8-substituted-7-fluoro-5-oxo-5H-thiazolo[3,2-a]quinoline-4-carboxylic acids

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