5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Base Information

Chemical Name:5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide
CAS No.:1258458-60-4
Molecular Formula:C₂₀H₁₅N₃O₄S
Molecular Weight:393.423
Hs Code.:

Synonyms:5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

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Chemical Property of 5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

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Technology Process of 5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

There total 11 articles about 5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258459-39-0
1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

: 99924-18-2
5-phenyl-1,3-oxazole-4-carboxylic acid

: 1258458-60-4
5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Guidance literature:: 5-phenyl-1,3-oxazole-4-carboxylic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1258459-32-3
[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-yl]-acetonitrile

: 1258458-60-4
5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate; hexamethyldisilathiane / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: ethanol / 0.5 h / Inert atmosphere; Reflux

3.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4.1: triethylamine; diphenyl phosphoryl azide / toluene / 2.08 h / 20 - 90 °C / Inert atmosphere

4.2: 1 h / Inert atmosphere; Reflux

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 17 h / 0 - 20 °C / Inert atmosphere

6.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

6.2: 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; hexamethyldisilathiane; diphenyl phosphoryl azide; water; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: Curtius Rearrangement / 4.2: Curtius Rearrangement;

Reference yield:

: 1161774-68-0
[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-yl]-methanol

: 1258458-60-4
5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: dimethyl sulfoxide / 0.75 h / 80 °C / Inert atmosphere

3.1: sodium methylate; hexamethyldisilathiane / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: ethanol / 0.5 h / Inert atmosphere; Reflux

5.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

6.1: triethylamine; diphenyl phosphoryl azide / toluene / 2.08 h / 20 - 90 °C / Inert atmosphere

6.2: 1 h / Inert atmosphere; Reflux

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 17 h / 0 - 20 °C / Inert atmosphere

8.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

8.2: 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; hexamethyldisilathiane; diphenyl phosphoryl azide; water; sodium methylate; benzotriazol-1-ol; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 6.1: Curtius Rearrangement / 6.2: Curtius Rearrangement;