methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate
CAS No.:1596341-35-3
Molecular Formula:C₂₉H₂₉F₃O₄
Molecular Weight:498.542
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

Suppliers and Price of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

There total 15 articles about methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1596341-34-2
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-[(trifluoromethane)sulfonyloxy]-6-(trifluoromethyl)phenyl]acetate

: 98-80-6
phenylboronic acid

: 1596341-35-3
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 85 ℃; Inert atmosphere;

Reference yield:

: 866615-03-4
1-fluoro-2-(methoxymethoxy)-4-(trifluoro methyl)benzene

: 1596341-35-3
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

3.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

5.2: 3 h / 0 - 60 °C / Inert atmosphere

6.1: methanol / cyclohexane; diethyl ether / 0.5 h / 0 - 20 °C

7.1: sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 0 °C

8.1: perchloric acid / water / 2 h / 0 - 20 °C / Inert atmosphere

9.1: hydrogen; palladium on activated charcoal / ethyl acetate / 40 °C

10.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

11.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; perchloric acid; palladium on activated charcoal; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1403382-20-6
ethyl 2-[3-fluoro-2-(methoxymethoxy)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596341-35-3
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-phenyl-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

2.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 3 h / 0 - 60 °C / Inert atmosphere

5.1: methanol / cyclohexane; diethyl ether / 0.5 h / 0 - 20 °C

6.1: sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 0 °C

7.1: perchloric acid / water / 2 h / 0 - 20 °C / Inert atmosphere

8.1: hydrogen; palladium on activated charcoal / ethyl acetate / 40 °C

9.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

10.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; palladium on activated charcoal; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;