Technology Process of methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-(tert-butoxy)acetate
There total 13 articles about methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-(tert-butoxy)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
perchloric acid;
In
cyclohexane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere
2.1: potassium tert-butylate; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
2.2: 0.75 h / -78 °C
3.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C
4.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere
5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 85 °C
5.2: 0.25 h / 0 - 20 °C
6.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
6.2: 4 h / 20 °C
6.3: 0.33 h / 0 - 20 °C
7.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C
8.1: perchloric acid / 1 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; n-butyllithium; perchloric acid; potassium tert-butylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; ISOPROPYLAMIDE; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C
2.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere
3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 85 °C
3.2: 0.25 h / 0 - 20 °C
4.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 20 °C
4.3: 0.33 h / 0 - 20 °C
5.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C
6.1: perchloric acid / 1 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; perchloric acid; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol; dichloromethane; ISOPROPYLAMIDE; water; mineral oil;
