methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate
CAS No.:1596341-33-1
Molecular Formula:C₂₃H₂₅F₃O₅
Molecular Weight:438.444
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate

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Chemical Property of methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate

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Technology Process of methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate

There total 13 articles about methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1403382-28-4
methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-(tert-butoxy)acetate

: 1596341-33-1
methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethyl acetate; at 40 ℃;

Reference yield:

: 1403382-27-3
methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

: 1596341-33-1
methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: perchloric acid / water / 2 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium on activated charcoal / ethyl acetate / 40 °C

With perchloric acid; palladium on activated charcoal; hydrogen; In water; ethyl acetate;

Reference yield:

: 1403382-20-6
ethyl 2-[3-fluoro-2-(methoxymethoxy)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596341-33-1
methyl 2-(tert-butoxy)-2-[2-(3 ,4-dihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

2.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 3 h / 0 - 60 °C / Inert atmosphere

5.1: methanol / cyclohexane; diethyl ether / 0.5 h / 0 - 20 °C

6.1: sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 0 °C

7.1: perchloric acid / water / 2 h / 0 - 20 °C / Inert atmosphere

8.1: hydrogen; palladium on activated charcoal / ethyl acetate / 40 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; palladium on activated charcoal; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;