2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride
CAS No.:1606974-14-4
Molecular Formula:C₂₄H₂₃ClN₄O₂*ClH
Molecular Weight:471.386
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride

There total 7 articles about 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1606976-65-1
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

: 1606974-14-4
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1606974-14-4
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 19 h

2.1: ammonia / methanol / 44 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 56 h / 760.05 Torr

4.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Microwave irradiation

5.1: hydrogenchloride / methanol

With hydrogenchloride; palladium 10% on activated carbon; ammonia; hydrogen; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2-(4-nitrobenzyl)propanediamide

: 1606974-14-4
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 56 h / 760.05 Torr

2: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Microwave irradiation

3: hydrogenchloride / methanol

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; ethyl acetate;