2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide
CAS No.:1606976-65-1
Molecular Formula:C₂₄H₂₃ClN₄O₂
Molecular Weight:434.925
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

There total 6 articles about 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 119822-23-0
2-(4-aminobenzyl)malonamide

: 1606976-40-2
4-chloro-2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine hydrochloride

: 1606976-65-1
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

Guidance literature:: With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 3h; Microwave irradiation;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1606976-65-1
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 19 h

2.1: ammonia / methanol / 44 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 56 h / 760.05 Torr

4.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Microwave irradiation

With hydrogenchloride; palladium 10% on activated carbon; ammonia; hydrogen; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2-(4-nitrobenzyl)propanediamide

: 1606976-65-1
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)malonamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 56 h / 760.05 Torr

2: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Microwave irradiation

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In 1-methyl-pyrrolidin-2-one; ethanol; ethyl acetate;