1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Base Information

Chemical Name:1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril
CAS No.:131632-25-2
Molecular Formula:C₂₂H₂₄N₂O₄
Molecular Weight:380.444
Hs Code.:

Synonyms:1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

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Chemical Property of 1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

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Technology Process of 1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

There total 4 articles about 1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 131632-63-8
1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

: 131632-25-2
1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Guidance literature:: With sodium hydroxide; In ethanol; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.44.725

Reference yield:

: 17336-11-7
2-acetoxy-4-methoxybenzoic acid

: 131632-25-2
1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

3: 81 percent / 5 N aq. NaOH / ethanol / 0.5 h / Ambient temperature

With sodium hydroxide; thionyl chloride; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725

Reference yield:

: 19202-27-8
2-acetoxy-4-methoxy-benzoyl chloride

: 131632-25-2
1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

2: 81 percent / 5 N aq. NaOH / ethanol / 0.5 h / Ambient temperature

With sodium hydroxide; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725