1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Base Information

• Chemical Name: 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril
• CAS No.: 131632-63-8
• Molecular Formula: C₂₄H₂₆N₂O₅
• Molecular Weight: 422.481
• Mol file: 131632-63-8.mol

Synonyms:1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Chemical Property of 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

There total 3 articles about 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetoxy-4-methoxy-benzoyl chloride (19202-27-8) + 1-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one (160587-12-2) → 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (131632-63-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 2h; Yield given;

DOI:10.1248/cpb.44.725

Reference yield:

2-acetoxy-4-methoxybenzoic acid (17336-11-7) → 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (131632-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.44.725

Reference yield:

→ 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (131632-63-8)

Guidance literature:

upstream raw materials:

2-acetoxy-4-methoxy-benzoyl chloride

1-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

2-acetoxy-4-methoxybenzoic acid

Downstream raw materials:

1-{1-[2-(3-Hydroxypropoxy)-4-methoxybenzoyl]-4-piperidinyl}-3,4-dihydrocarbostyril

1-[1-(2-Hydroxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril