methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

Base Information

Chemical Name:methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate
CAS No.:203940-50-5
Molecular Formula:C₂₄H₂₄ClNO₅S₂
Molecular Weight:506.043
Hs Code.:

Synonyms:methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

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Chemical Property of methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

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Technology Process of methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

There total 10 articles about methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

: 203940-49-2,203940-56-1,203940-58-3
methyl (±)-4-({[2-amino-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 203940-50-5
methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 4h; Cooling with ice;
DOI:10.1246/bcsj.20130261

Reference yield:

: 68348-23-2
3-(1,3-dioxolan-2-yl)benzaldehyde

: 203940-50-5
methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / methanol / 2 h / Cooling with ice

2: hydrogenchloride / methanol; water / 2 h / 20 °C

3: N-butylamine / benzene / 1 h / Reflux

4: acetic acid / 2 h / 80 °C

5: acetic acid / 0.5 h / 80 °C

6: acetic acid; zinc / methanol / 4 h / 50 °C

7: triethylamine / 1,2-dichloro-ethane / 4 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tetrahydroborate; acetic acid; N-butylamine; triethylamine; zinc; In methanol; water; acetic acid; 1,2-dichloro-ethane; benzene;
DOI:10.1246/bcsj.20130261

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 203940-50-5
methyl 4-({[2-(4-chlorophenylsulfonylamino)-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 1.5 h / Cooling with ice

2: sodium hydroxide / methanol; tetrahydrofuran; water / 0.5 h / Cooling with ice

3: acetic acid / 0.5 h / 80 °C

4: acetic acid; zinc / methanol / 4 h / 50 °C

5: triethylamine / 1,2-dichloro-ethane / 4 h / 20 °C / Cooling with ice

With acetic acid; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.20130261