(S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride

Base Information

• Chemical Name: (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride
• CAS No.: 123665-42-9
• Molecular Formula: C₁₁H₁₆N₂O*ClH
• Molecular Weight: 228.722
• Mol file: 123665-42-9.mol

Synonyms:(S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride

Chemical Property of (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride

There total 6 articles about (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(S)-tert-butyl 1-(dimethylamino)-1-oxo-3-phenylpropan-2-ylcarbamate (78800-68-7) → (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride (123665-42-9,1175090-79-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02830

Reference yield:

→ N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester (7535-56-0) + (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride (123665-42-9,1175090-79-5)

Guidance literature:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride (123665-42-9,1175090-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / CH₂Cl₂ / 18 h / 0 - 20 °C

2: HCl / dioxane / 1 h / 23 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm980264k

upstream raw materials:

(S)-tert-butyl 1-(dimethylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

N-tert-butoxycarbonyl-L-phenylalanine

dimethyl amine

Downstream raw materials:

N-Acetylphenylalanylphenylalanine dimethylamide

5-Chloro-1H-benzoimidazole-2-carboxylic acid (1-dimethylcarbamoyl-2-phenyl-ethyl)-amide

N,N-dimethyl-N²-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-L-phenylalaninamide

N-[(2S)-2-amino-3-phenylpropyl]-N,N-dimethylamine