78800-68-7

Basic information

• Product Name: Carbamic acid, [(1S)-2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 78800-68-7
• Molecular Formula: C16H24N2O3
• Molecular Weight: 292.378
• Mol File: 78800-68-7.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(78800-68-7)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-(dimethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(78800-68-7)

Safety Data

• Hazardous Substances Data: 78800-68-7(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 
• 3674-06-4 Boc-Phe-ONSu 
• 110-89-4 piperidine 
• 1274754-60-7 S-(tert-butyl) (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanethioate 
• 68-12-2 N,N-dimethyl-formamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63-91-2 L-phenylalanine 

Downstream Products

• 1351960-32-1 L-Phe-dimethylamide-isothiocyanate 
• 1351960-33-2 C₁₆H₂₅N₅O₂S 
• 340161-69-5 tert-butyl (S)-(1-(dimethylamino)-3-phenylpropan-2-yl)carbamate 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides

The asymmetric transfer hydrogenation (ATH) of α-keto-1,4-diamides using a tethered Ru/TsDPEN catalyst was achieved in high ee. Studies on derivatives identified the structural elements which lead to the highest enantioselectivities in the products. The α-keto-amide reduction products have been converted to a range of synthetically valuable derivatives.

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

Asymmetric hydroazidation of α-substituted vinyl ketones catalyzed by chiral primary amine

We report herein the first example of asymmetric hydroazidation of α-substituted vinyl ketones by using chiral primary amines as the catalysts. A simple chiral primary-tertiary diamine catalyst derived from L-phenylalanine was found to readily promote this aza-Michael addition reaction with enamine protonation as the key stereogenic step, thus enabling the effective synthesis of α-chiral β-azido ketones with good yields and moderate enantioselectivities.