Flutroline

Base Information

Chemical Name:Flutroline
CAS No.:70801-02-4
Molecular Formula:C27H25F3N2O
Molecular Weight:450.504
Hs Code.:
Mol file:70801-02-4.mol

Synonyms:CP 36584;62655-22-5;FLUTROLINE;Flutrolinum [INN-Latin];2H-Pyrido[4,3-b]indole-2-butanol,8-fluoro- R,5-bis(4-fluorophenyl)-1,3,4,5-tetrahydro-;Flutroline [USAN:INN];CP 36,584;2H-Pyrido(4,3-b)indole-2-butanol, 8-fluoro-alpha,5-bis(4-fluorophenyl)-1,3,4,5-tetrahydro-, (+-)-;Flutrolino [INN-Spanish];(+-)-8-Fluoro-alpha,5-bis(p-fluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido(4,3-b)indole-2-butanol;

Suppliers and Price of Flutroline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-[8-FLUORO-5-(4-FLUOROPHENYL)-1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOL-2-YL]-1-(4-FLUOROPHENYL)-1-BUTANOL 95.00%
5MG
$ 495.53

Total 2 raw suppliers

Chemical Property of Flutroline

Chemical Property:

Vapor Pressure:2.57E-15mmHg at 25°C
Refractive Index:1.613
Boiling Point:601.5°C at 760 mmHg
Flash Point:317.5°C
PSA：28.40000
Density:1.28g/cm³
LogP:5.85760

Purity/Quality:

99% ^*data from raw suppliers

4-[8-FLUORO-5-(4-FLUOROPHENYL)-1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOL-2-YL]-1-(4-FLUOROPHENYL)-1-BUTANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Antipsychotic.

Technology Process of Flutroline

There total 7 articles about Flutroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58038-66-7
2-carbethoxy-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido<4,3-b>indole

: 70801-02-4,62655-22-5
8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-hydroxybutyl>-2,3,4,5-tetrahydro-1H-pyridio<4,3-b>indole

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / cuprous bromide, sodium carbonate / various solvent(s) / 8 h / 200 °C

2: 41 percent / KOH, water / ethanol / 23 h / Heating

3: NaCO₃, KI / dimethylformamide / 4 h / 65 °C

4: NaBH₄ / ethanol; tetrahydrofuran / 0.5 h

With potassium hydroxide; sodium tetrahydroborate; water; sodium carbonate; potassium iodide; copper(I) bromide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a011

Reference yield:

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 70801-02-4,62655-22-5
8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-hydroxybutyl>-2,3,4,5-tetrahydro-1H-pyridio<4,3-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: NaCO₃, KI / dimethylformamide / 4 h / 65 °C

2: NaBH₄ / ethanol; tetrahydrofuran / 0.5 h

With sodium tetrahydroborate; potassium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a011

Reference yield:

: 58038-67-8
2-carbethoxy-8-fluoro-5-(4-fluorophenyl)-1,2,3,4-tetrahydro-γ-carboline

: 70801-02-4,62655-22-5
8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-hydroxybutyl>-2,3,4,5-tetrahydro-1H-pyridio<4,3-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / KOH, water / ethanol / 23 h / Heating

2: NaCO₃, KI / dimethylformamide / 4 h / 65 °C

3: NaBH₄ / ethanol; tetrahydrofuran / 0.5 h

With potassium hydroxide; sodium tetrahydroborate; water; potassium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a011