Technology Process of ethyl 5-(benzoyloxy)-2-(1-(benzyloxycarbonylamino)-4,4-bis(tosyloxymethyl)cyclohexyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate
There total 10 articles about ethyl 5-(benzoyloxy)-2-(1-(benzyloxycarbonylamino)-4,4-bis(tosyloxymethyl)cyclohexyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: toluene-4-sulfonic acid / benzene / 48 h / 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice
2.2: 1.5 h / -5 - 30 °C
3.1: pyridine / dmap / 48 h / 20 °C
4.1: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 52 °C
5.1: ammonium hydroxide; ammonium chloride / tetrahydrofuran; methanol
6.1: sodium carbonate monohydrate / dichloromethane; water / 2.5 h / 20 °C / Inert atmosphere
7.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux
8.1: tetrahydrofuran / Reflux
9.1: dichloromethane; xylene / 24 h / 115 °C
10.1: pyridine / 20 h / 20 °C
With
pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sodium carbonate monohydrate; water; hydroxylamine; ammonium chloride;
dmap; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; xylene; benzene;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: water; sodium chloride / dimethyl sulfoxide / 3.5 h / 160 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / benzene / 48 h / 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice
3.2: 1.5 h / -5 - 30 °C
4.1: pyridine / dmap / 48 h / 20 °C
5.1: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 52 °C
6.1: ammonium hydroxide; ammonium chloride / tetrahydrofuran; methanol
7.1: sodium carbonate monohydrate / dichloromethane; water / 2.5 h / 20 °C / Inert atmosphere
8.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux
9.1: tetrahydrofuran / Reflux
10.1: dichloromethane; xylene / 24 h / 115 °C
11.1: pyridine / 20 h / 20 °C
With
pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sodium carbonate monohydrate; water; hydroxylamine; ammonium chloride; sodium chloride;
dmap; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; xylene; benzene;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: acetic anhydride; pyridine / 3 h / Reflux
1.2: 16 h
2.1: toluene-4-sulfonic acid / benzene / 48 h / 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice
3.2: 1.5 h / -5 - 30 °C
4.1: pyridine / dmap / 48 h / 20 °C
5.1: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 52 °C
6.1: ammonium hydroxide; ammonium chloride / tetrahydrofuran; methanol
7.1: sodium carbonate monohydrate / dichloromethane; water / 2.5 h / 20 °C / Inert atmosphere
8.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux
9.1: tetrahydrofuran / Reflux
10.1: dichloromethane; xylene / 24 h / 115 °C
11.1: pyridine / 20 h / 20 °C
With
pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sodium carbonate monohydrate; water; hydroxylamine; acetic anhydride; ammonium chloride;
dmap; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; xylene; benzene;
