Technology Process of 1-{[(5-{3-fluoro-4-[5-(trifluoromethyl)-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]methyl}cyclobutanecarboxylic acid
There total 6 articles about 1-{[(5-{3-fluoro-4-[5-(trifluoromethyl)-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]methyl}cyclobutanecarboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-{[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]methyl}cyclobutanecarboxylic acid;
With
water; trifluoroacetic acid;
at 50 ℃;
for 3h;
With
sodium hydrogencarbonate;
In
water;
pH=4;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 3 h / 60 °C
2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere
3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 65 °C / Inert atmosphere
4.1: water; sodium hydroxide / methanol / 1 h / Reflux
5.1: water; trifluoroacetic acid / 3 h / 50 °C
5.2: pH 4
With
water; potassium acetate; sodium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 3 h / 60 °C
2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere
3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 65 °C / Inert atmosphere
4.1: water; sodium hydroxide / methanol / 1 h / Reflux
5.1: water; trifluoroacetic acid / 3 h / 50 °C
5.2: pH 4
With
water; potassium acetate; sodium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;