5-Bromo-2-hydroxy-4-methylpyridine

Base Information

• Chemical Name: 5-Bromo-2-hydroxy-4-methylpyridine
• CAS No.: 164513-38-6
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.024
• Hs Code.: 2933399090
• European Community (EC) Number: 624-534-4
• DSSTox Substance ID: DTXSID20356137
• Nikkaji Number: J3.141.855K
• Wikidata: Q72456921
• Mol file: 164513-38-6.mol

Synonyms:5-Bromo-2-hydroxy-4-methylpyridine;164513-38-6;5-bromo-4-methylpyridin-2-ol;5-Bromo-4-methyl-2(1H)-pyridinone;5-Bromo-2-hydroxy-4-picoline;5-bromo-4-methyl-1H-pyridin-2-one;5-bromo-4-methyl-2-pyridinol;MFCD03427664;5-bromo-4-methyl-pyridin-2-ol;2-HYDROXY-4-METHYL-5-BROMOPYRIDINE;SCHEMBL457547;DTXSID20356137;BYGNXKDNIFHZHQ-UHFFFAOYSA-N;5-bromo-4-methyl-2(1h)pyridone;5-bromo-4-methylpyridin-2(1h)-one;BBL101682;MFCD10465387;STL555478;3-Bromo-6-hydroxy-4-methyl pyridine;AKOS002664325;AKOS016352899;AB15096;AM62373;CS-W016833;FS-2150;AC-27501;SY029074;5-Bromo-2-hydroxy-4-methylpyridine, 97%;A3652;B4701;FT-0645893;EN300-97760;AN-584/42482460;W-205936;Z1251353595

Chemical Property of 5-Bromo-2-hydroxy-4-methylpyridine

Chemical Property:

• Appearance/Colour: light yellow powder
• Vapor Pressure: 0.0019mmHg at 25°C
• Melting Point: 198-202 °C(lit.)
• Refractive Index: 1.573
• Boiling Point: 339.893 °C at 760 mmHg
• PKA: 9.99±0.10(Predicted)
• Flash Point: 159.362 °C
• PSA: 33.12000
• Density: 1.656 g/cm³
• LogP: 1.85810
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 186.96328
• Heavy Atom Count: 9
• Complexity: 205

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-4-methyl-2(1H)-pyridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC(=O)NC=C1Br
• Uses: It is used for medicine.

Technology Process of 5-Bromo-2-hydroxy-4-methylpyridine

There total 2 articles about 5-Bromo-2-hydroxy-4-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2-amino-5-bromo-4-methylpyridine (98198-48-2) → 2-hydroxy-5-bromo-4-methylpyridine (164513-38-6)

Guidance literature:

With sodium nitrite; In sulfuric acid; water;

Reference yield:

2-hydroksy-4-methyl-pyridine (13466-41-6,91914-05-5) → 3,5-dibromo-2-hydroxy-4-methylpyridine (89581-53-3) + 2-hydroxy-5-bromo-4-methylpyridine (164513-38-6) + 3-bromo-2-hydroxy-4-methylpyridine (18368-59-7)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; Title compound not separated from byproducts;

DOI:10.1055/s-2003-41013

Reference yield: 93.0%

5-bromo-4-methylpyridin-2(1H)-one (164513-38-6) + benzyl bromide (100-39-0) → 2-(benzyloxy)-5-bromo-4-methylpyridine (847349-87-5)

Guidance literature:

With silver carbonate; In benzene; at 20 ℃; for 96h;

DOI:10.1016/j.bmc.2009.05.069

upstream raw materials:

2-amino-5-bromo-4-methylpyridine

2-hydroksy-4-methyl-pyridine

Downstream raw materials:

5-bromo-2-methoxy-4-methylpyridine

3-bromo-4-bromomethyl-6-methoxypyridine

2-(benzyloxy)-5-bromo-4-methylpyridine

5-bromo-2-(difluoromethoxy)-4-methylpyridine

Refernces

• 1、 -. "(Hetero)-aryl ketones derivatives with antibacterial properties". . . Retrieved 2008/06/13.