188047-58-7

Upstream product

• 10026-13-8 phosphorus pentachloride 
• 83-10-3 antipyric acid 
• 1140-38-1 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4?carboxylic acid 
• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 89-25-8 edaravone 
• 100-63-0 phenylhydrazine 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 

Downstream Products

• 681841-65-6 3-methyl-1,7-diphenyl-1H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-a]pyrimidin-4(5H)-one 
• 777861-25-3 1-phenyl-3-methyl-1H-pyrazolo[4,3-e][1,2,4]triazolo[2,3-a]pyrimidin-4(5H)-one 
• 777861-24-2 1-phenyl-3-methyl-1H-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-4(9H)-one 
• 188047-59-8 C₁₂H₈ClN₃OS 
• 1392131-63-3 1-(4-bromo-2-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-64-4 1-(2-fluorobenzyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-65-5 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-66-6 1-(2-fluoro-3-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-67-7 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 

Relevant academic research and scientific papers

Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides

The pyrazole core has been recognized by their biological properties and included in the synthesis of modern agrochemicals. Part of these studies consists of making structural modifications to pesticides for commercial purposes to increase efficacy. In th

Design, Synthesis, DFT study and antifungal activity of pyrazolecarboxamide derivatives

A series of novel pyrazole amide derivatives were designed and synthesized by multi-step reactions from phenylhydrazine and ethyl 3-oxobutanoate as starting materials, and their structures were characterized by NMR, MS and elemental analysis. The antifungal activity of the title compounds was determined. The results indicated that some of title compounds exhibited moderate antifungal activity. Furthermore, DFT calculations were used to study the structure-activity relationships (SAR).

Pyrazole amides compound, preparation method therefor and application thereof

The present invention discloses a pyrazole amides compound. The structural formula of the compound is as shown in the description, wherein R is optionally substituted with one or more substituents of C1-C6 alkyl, alkoxy, halogen, nitro, and trifluoromethyl. The present invention also discloses a preparation method for the pyrazole amides compound. The pyrazole amides compound can be used for antibacterium, in particular for prevention and control of tomato late blight, tomato damping-off, corynespora cassiicola, botrytis cinerea, and cucumber sheath blight. The pyrazole amides compound can also be used for weeding, in particular for prevention and control of barnyard grass and rape.

Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl) prop-2-yn-1-ones with amines

A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)- one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions. The Royal Society of Chemistry 2012.

Synthesis and bioactivity of pyrazole acyl thiourea derivatives

Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3- methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3- methyl -1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, 1H-NMR, 13C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests.

Heterocyclic analogues of xanthone and xanthione. 1H-pyrano[2,3-c:6,5-c] dipyrazol-4(7H)-ones and thiones: Synthesis and NMR data

The synthesis of the title compounds is described. Reaction of 1-substituted 2-pyrazolin-5-ones with 5-chloro-1-phenyl-1H-pyrazole-4-carbonyl chloride or 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl chloride, respectively, using calcium hydroxide in refluxing 1,4-dioxane gave the corresponding 4-heteroaroylpyrazol-5-ols, which were cyclized into 1H-pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones by treatment with K 2CO3/DMF. The latter were converted into the corresponding thiones upon reaction with Lawesson's reagent. Detailed NMR spectroscopic investigations (1H, 13C, 15N) of the ring systems and their precursors are presented.

Synthesis of pyrazolotriazolopyrimidine tri-fused heterocyclic compounds

This paper uses basic-catalysed method to convert 1H-pyrazole-4-carboxamides into tri-fused heterocyclic systems containing two kinds of pyrazolotriazolopyrimidine framework. The synthesis of compounds 5-6 and reactions of them with some electrophiles hav

Synthesis of 5-chloro-3-methyl-1 phenyl-1H pyrazole-4-carboxylic acd heterocyclic-2-ylamide

Reaction of 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl chloride 4 with substituted benzothiazol-2-ylamine and substituted [1,3,4] thiadiazol-2-ylamine yields 5-chloro-3-methyl-1-phenyl-1H pyrazole-4-carboxylic acid-substituted benzothiazol-2-ylamid