1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine

Base Information

• Chemical Name: 1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine
• CAS No.: 1013333-17-9
• Molecular Formula: C₁₉H₃₁NOSi
• Molecular Weight: 317.547
• Mol file: 1013333-17-9.mol

Synonyms:1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine

Chemical Property of 1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine

There total 1 articles about 1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol (158984-76-0) → 1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine (1013333-17-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/j.tet.2007.12.055

Reference yield: 83.0%

1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine (1013333-17-9) → trans-1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]piperidin-3-ol

Guidance literature:

1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine; With borane; In tetrahydrofuran; at -30 - 20 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; for 4h; Further stages.; Heating;

DOI:10.1016/j.tet.2007.12.055

upstream raw materials:

tert-butyldimethylsilyl chloride

1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol