(2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

Base Information

Chemical Name:(2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester
CAS No.:115141-86-1
Molecular Formula:C₂₁H₃₀N₂O₅
Molecular Weight:390.48
Hs Code.:

(2S)-2-<(3S)-3-<N-(benzyloxycarbonyl)-N-methylamino>-2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

Synonyms:(2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

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Chemical Property of (2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

Chemical Property:

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Technology Process of (2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

There total 5 articles about (2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115141-92-9
(2S)-2--5-(p-tolylsulfonyl)pentanoyl-L-leucine methyl ester

: 115141-86-1
(2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

Guidance literature:: With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 3h;
DOI:10.1021/jm00117a022

Reference yield:

: 23632-67-9
(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid

: 115141-86-1
(2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 11.0 g / BH₃*THF, diborane / tetrahydrofuran / 1.) -25 deg C, 1 h, 2.) 0 deg C, 4 h

2: 13.35 g / pyridine / CH₂Cl₂ / Ambient temperature

3: 58 percent / triethylsilane, TFA / CH₂Cl₂ / 22 h / Ambient temperature

4: 95 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride, diisopropylethylamine / CH₂Cl₂ / 0 deg C -> room temperature, overnight

5: 0.88 g / NaH / dimethylformamide; CH₂Cl₂ / 3 h / 0 °C

With pyridine; triethylsilane; borane-THF; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diborane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a022

Reference yield:

: 115141-89-4
(4S)-3-(benzyloxycarbonyl)-4-(3-hydroxypropyl)-1,3-oxazolidin-5-one

: 115141-86-1
(2S)-2-<(3S)-3--2-oxo-1-piperidinyl>-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 13.35 g / pyridine / CH₂Cl₂ / Ambient temperature

2: 58 percent / triethylsilane, TFA / CH₂Cl₂ / 22 h / Ambient temperature

3: 95 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride, diisopropylethylamine / CH₂Cl₂ / 0 deg C -> room temperature, overnight

4: 0.88 g / NaH / dimethylformamide; CH₂Cl₂ / 3 h / 0 °C

With pyridine; triethylsilane; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a022