115141-89-4

Upstream product

• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 1155-62-0 N-benzyloxycarbonyl-DL-glutamic acid 
• 23632-67-9 (S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid 

Downstream Products

• 115141-97-4 (S)-4-(3-Acetoxy-propyl)-5-oxo-oxazolidine-3-carboxylic acid benzyl ester 
• 173440-84-1 (4S)-3-(benzyloxycarbonyl)-4-(3-triethylsiloxypropyl)-1,3-oxazolidin-5-one 
• 173440-69-2 (4S)-3-(benzyloxycarbonyl)-4-(3-methoxymethoxypropyl)-1,3-oxazolidin-5-one 
• 82361-46-4 (2R,6S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-heptanedioic acid 7-methyl ester 
• 160579-23-7 methyl (Z,S)-5-(3-benzyloxycarbonyl-5-oxo-1,3-oxazolidin-4-yl)-2-[(tert-butyloxycarbonyl)amino]-2-pentenoate 
• 160806-00-8 7-methyl 1-[2-(trimethylsilyl)ethyl] (2S,6R)-N^α-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-2,6-diaminopimelate 
• 478920-12-6 7-methyl 1-[2-(trimethylsilyl)ethyl] (2S,6S)-N^α-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-2,6-diaminopimelate 
• 160579-14-6 methyl [7-methyl(2S,6R)-N^α-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-2,6-diaminopimelyl]-D-alaninate 
• 478920-11-5 1-methyl 7-[2-(trimethylsilyl)] (Z,S)-6-[(benzyloxycarbonyl)-amino]-2-[(tert-butyloxycarbonyl)amino]-2-heptenedioate 
• 478920-26-2 methyl [7-methyl (2S,6R)-N^α-(N-benzyloxycarbonyl-D-isoglutamyl α-methyl ester)-N^ε-(tert-butyloxycarbonyl)-2,6-diaminopimelyl]-D-alaninate 
• 478920-23-9 7-methyl 1-[2-(trimethylsilyl)ethyl] (2S,6S)-N^α-(N-benzyloxycarbonyl-D-isoglutamyl α-methyl ester)-N^ε-(tert-butyloxycarbonyl)-2,6-diaminopimelate 
• 478920-22-8 7-methyl 1-[2-(trimethylsilyl)ethyl] (2S,6R)-N^α-(N-benzyloxycarbonyl-D-isoglutamyl α-methyl ester)-N^ε-(tert-butyloxycarbonyl)-2,6-diaminopimelate 
• 478920-25-1 7-methyl 1-[2-(trimethylsilyl)ethyl] (2S,6S)-N^α-[(N-benzyloxycarbonyl-L-alanyl)-D-isoglutamyl α-methyl ester]-N^ε-(tert-butyloxycarbonyl)-2,6-diaminopimelate 
• 478920-24-0 (2S,6R)-2-[(R)-4-((S)-2-Benzyloxycarbonylamino-propionylamino)-4-methoxycarbonyl-butyrylamino]-6-tert-butoxycarbonylamino-heptanedioic acid 7-methyl ester 1-(2-trimethylsilanyl-ethyl) ester 

Relevant academic research and scientific papers

N-METHYL AMINO ACIDS

The present invention relates to a compound of formula (I) or (II), processes for preparing them, peptides including them and kits involving them.

Synthesis of muramyl peptides containing meso-diaminopimelic acid

Chain-extension of L-glutamate aldehyde 3 by means of the Wittig-Horner reaction furnished the desired C7 dicarboxylic acid derivative, which in turn, after C-C double bond hydrogenation and protecting group manipulation, afforded the 2,6-diaminopimelic acid derivatives (S,R)-9 and (S,S)-9, both with the desired orthogonal protecting group pattern. Synthesis of the muramic acid derivative 15 and attachment of an L-alanine residue furnished muramyl-L-alanine 18. The corresponding 1,6-anhydromuramic acid derivative 26 was obtained similarly. Treatment of these compounds with peptides 28-30 and with the 2,6-diaminopimelic acid containing di- and tripeptides 32a, 32b, and 35 gave the protected muramyl peptides 17, 37, 40, 42, 44, 46, and 49a and 49b, which, after deprotection, afforded the desired target molecules muramyl-L-alanine (38), muramyl-L-alanyl-D-glutamic acid (39), muramyl-L-alanyl-D-glutaminide (41), muramyl-L-alanyl-D- isoglutaminyl-L-lysine (43), muramyl-L-alanyl-D-isoglutaminyl-(2S,6R)-2,6-diaminopimelic acid (45), muramyl-L-alanyl- L-isoglutaminyl-(2S,6R)-2,6-diaminopimelic-D-alanme (47), 1,6-anhydromuramyl-L-alanyl-D-isoglutaminyl-(2S,6R)-2,6-diaminopimelic acid (50a), and 1,6-anhydromuramyl-L-alanyl-D- isoglutaminyl-(2S,6S)-2,6-diaminiopimelic acid (50b). ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).

Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics

A simple experimental procedure on solid phase for the construction of new tripeptidic 5,9- and 5,10-fused thiazabicycloalkane scaffolds that adopt β-turns has been developed. This N-terminal-directed bicyclization, relying on masked aldehyde precursors d

Lactam-conformationally restricted analogs of N(α)-arylsulfonyl arginine amide: Design, synthesis and inhibitory activity toward thrombin and related enzymes

Three new lactam-conformationally restricted arginine derivatives, 1- butyl-3-(6,7-dimethoxy-2-naphthylsulfonyl)-3-(3-guanidinopropyl)-substituted γ-, δ-, and ε-lactams (2-4), were synthesized on the basis of backbone modification of the lead structure, 6

Azacycle Synthesis via Radical Cyclization of β-Aminoacrylates.

(Pyrrolidine)- and (piperidine)acetates are efficiently synthesized via radical cyclization of β-aminoacrylates.

AN ASYMMETRIC SYNTHESIS OF DIFFERENTIALLY PROTECTED MESO-2,6-DIAMINOPIMELIC ACID

Differentially protected meso-2,6-diaminopimelic acid, a component of bacterial cell walls, a biosynthetic precursor of L-lysine and a constituent of several synthetic immunostimulants, has been prepared stereospecifically from L-glutamic acid.

Synthesis, conformation, and immunosuppressive activitiy of a conformationally restricted cyclosporine lactam analogue

Cyclosporine A (CsA, 1), an immunosuppressive cyclic undecapeptide, in apolar solvents adopts a II' β-turn at the Sar3-MeLeu4 residues. [D-Proline3]Cs has been reported to be a nonimmunosuppressive analogue in which the II