5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Base Information

Chemical Name:5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide
CAS No.:869295-00-1
Molecular Formula:C₁₇H₁₃F₂N₃O₃
Molecular Weight:345.305
Hs Code.:

Synonyms:5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

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Chemical Property of 5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Chemical Property:

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Technology Process of 5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

There total 6 articles about 5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869294-99-5
ethyl 5,6-difluoro-4-oxo-3,4-dihydroquinazoline-2-carboxylate

: 5071-96-5
3-METHOXYBENZYLAMINE

: 869295-00-1
5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 869299-06-9
ethyl 5,6-difluoroanthranilate hydrochloride

: 869295-00-1
5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; acetic acid / water / 3 h / 80 °C

2: triethylamine / tetrahydrofuran / 48 h / 20 °C

With hydrogenchloride; acetic acid; triethylamine; In tetrahydrofuran; water;

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 869295-00-1
5,6-difluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 60 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

2.2: 1.75 h / -78 - 0 °C

3.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 1.17 h / 0 - 20 °C

4.1: hydrogenchloride; acetic acid / water / 3 h / 80 °C

5.1: triethylamine / tetrahydrofuran / 48 h / 20 °C

With hydrogenchloride; n-butyllithium; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexanes; water; ethyl acetate;