(6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

Base Information

Chemical Name:(6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol
CAS No.:1432905-82-2
Molecular Formula:C₂₉H₅₈O₃Si
Molecular Weight:488.816
Hs Code.:

(6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

Synonyms:(6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

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Chemical Property of (6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

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Technology Process of (6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

There total 1 articles about (6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1432905-81-1
ethyl (5S)-5-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-9-hydroxy-9-methyl-decanoate

: 41251-37-0
methyl-d3-magnesium iodide

: 1432905-82-2
(6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

Guidance literature:: In diethyl ether; at 20 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1021/jm400032t

Reference yield:

: 1432905-82-2
(6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

: 1432905-67-3
1,25-dihydroxy-21-(3-hydroxy-3-trideuteriomethyl-4,4,4-trideuteriobut-1-yl)-cholecalciferol

Guidance literature:: Multi-step reaction with 5 steps

1.1: fluorosilicic acid / acetonitrile / 15 h / Inert atmosphere

2.1: dipyridinium dichromate / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 4 h / Inert atmosphere

3.1: cyclohexane / Inert atmosphere

4.1: phenyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C / Inert atmosphere

4.2: -65 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 29 h / 20 °C / Inert atmosphere

With dipyridinium dichromate; fluorosilicic acid; tetrabutyl ammonium fluoride; phenyllithium; In tetrahydrofuran; hexane; cyclohexane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; acetonitrile;
DOI:10.1021/jm400032t

Reference yield:

: 1432905-82-2
(6S)-6-[(1R,3aR,4S,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7amethyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]-1,1,1-trideuterio-10-methyl-2-(trideuteriomethyl)undecane-2,10-diol

: 1432906-00-7
1,25-dihydroxy-21-(3-hydroxy-3-trideuteriomethyl-4,4,4-trideuteriobut-1-yl)-19-nor-cholecalciferol

Guidance literature:: Multi-step reaction with 5 steps

1.1: fluorosilicic acid / acetonitrile / 15 h / Inert atmosphere

2.1: dipyridinium dichromate / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 4 h / Inert atmosphere

3.1: cyclohexane / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C / Inert atmosphere

4.2: -65 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 47 h / 20 °C / Inert atmosphere

With dipyridinium dichromate; n-butyllithium; fluorosilicic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane; cyclohexane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; acetonitrile;
DOI:10.1021/jm400032t