N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

Base Information

Chemical Name:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide
CAS No.:1361330-39-3
Molecular Formula:C₂₂H₂₀Cl₂N₄O₃S
Molecular Weight:491.398
Hs Code.:

Synonyms:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

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Chemical Property of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

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Technology Process of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

There total 4 articles about N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1361330-41-7
1,1-dimethylethyl [(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

: 1361330-40-6
1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

: 1361330-42-8
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-3-chlorobenzenesulfonamide

: 1361330-39-3
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield: 4.0%

: 1361330-38-2
2,3-dichloro-N-[1-[(3-cyanophenyl)methyl]-4-(methyloxy)-1H-indazol-3-yl]benzenesulfonamide

: 1361330-39-3
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2h;

Reference yield:

: 94088-46-7
2-fluoro-6-methoxybenzonitrile

: 1361330-39-3
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3: pyridine / 2 h / 20 °C

4: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; butan-1-ol;