1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate
CAS No.:1361330-40-6
Molecular Formula:C₂₇H₂₈Cl₂N₄O₅S
Molecular Weight:591.515
Hs Code.:

Synonyms:1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

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Chemical Property of 1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

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Technology Process of 1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

There total 5 articles about 1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1361330-39-3
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2,3-dichlorobenzenesulfonamide

: 1361330-41-7
1,1-dimethylethyl [(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

: 1361330-40-6
1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; methanol; at 0 ℃; for 0.5h;

Reference yield:

: 94088-46-7
2-fluoro-6-methoxybenzonitrile

: 1361330-41-7
1,1-dimethylethyl [(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

: 1361330-40-6
1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3: pyridine / 2 h / 20 °C

4: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 - 20 °C

5: sodium tetrahydroborate; nickel dichloride / tetrahydrofuran; methanol / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrazine hydrate; potassium hydroxide; nickel dichloride; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; butan-1-ol;

Reference yield:

: 886362-07-8
4-(methyloxy)-1H-indazol-3-amine

: 1361330-41-7
1,1-dimethylethyl [(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

: 1361330-40-6
1,1-dimethylethyl [(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

2: pyridine / 2 h / 20 °C

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 - 20 °C

4: sodium tetrahydroborate; nickel dichloride / tetrahydrofuran; methanol / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; potassium hydroxide; nickel dichloride; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide;