1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Base Information

• Chemical Name: 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
• CAS No.: 1325297-12-8
• Molecular Formula: C₁₆H₁₅NO₅
• Molecular Weight: 301.299
• Mol file: 1325297-12-8.mol

Synonyms:1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Chemical Property of 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

There total 4 articles about 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate (1325297-11-7) → 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (1325297-12-8)

Guidance literature:

diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate; With potassium hydroxide; In ethanol; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.1021/ja206457b

Reference yield:

diethyl 4-oxo-1,4-dihydro-3,5-pyridinedicarboxylate (74632-03-4) → 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (1325297-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: potassium hydroxide / ethanol / 20 °C

With potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja206457b

Reference yield:

benzyl bromide (100-39-0) → 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (1325297-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: potassium hydroxide / ethanol / 20 °C

With potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja206457b

upstream raw materials:

diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate

benzyl bromide

diethyl 4-oxo-1,4-dihydro-3,5-pyridinedicarboxylate

diethyl 1,3-acetonedicarboxylate

Downstream raw materials:

C₂₈H₂₆N₄O₅

ethyl 1-benzyl-5-(1-benzyl-5-(1-benzyl-5-(1-benzyl-5-(tert-butoxycarbonylamino)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxylate

methyl 1-benzyl-5-(1-benzyl-5-(tert-butoxycarbonylamino)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxylate

methyl 1-benzyl-5-(1-benzyl-4-oxo-5-(2,2,2-trifluoroacetamido)-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxylate