diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 1325297-11-7
• Molecular Formula: C₁₈H₁₉NO₅
• Molecular Weight: 329.353
• Mol file: 1325297-11-7.mol

Synonyms:diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate

There total 2 articles about diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzyl bromide (100-39-0) + diethyl 4-oxo-1,4-dihydro-3,5-pyridinedicarboxylate (74632-03-4) → diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate (1325297-11-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 10h;

DOI:10.1021/ja206457b

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate (1325297-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: urea / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 150 °C

2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

With potassium carbonate; urea; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;

DOI:10.1021/ja206457b

Reference yield: 46.0%

diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate (1325297-11-7) → 1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (1325297-12-8)

Guidance literature:

diethyl 1-benzyl-4-oxo-1,4-dihydropyridine-3,5-dicarboxylate; With potassium hydroxide; In ethanol; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.1021/ja206457b

upstream raw materials:

benzyl bromide

diethyl 4-oxo-1,4-dihydro-3,5-pyridinedicarboxylate

diethyl 1,3-acetonedicarboxylate

Downstream raw materials:

C₂₈H₂₆N₄O₅

ethyl 1-benzyl-5-(1-benzyl-5-(1-benzyl-5-(1-benzyl-5-(tert-butoxycarbonylamino)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxylate

methyl 1-benzyl-5-(1-benzyl-5-(tert-butoxycarbonylamino)-4-oxo-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxylate

methyl 1-benzyl-5-(1-benzyl-4-oxo-5-(2,2,2-trifluoroacetamido)-1,4-dihydropyridine-3-carboxamido)-4-oxo-1,4-dihydropyridine-3-carboxylate