ethyl 2-fluoro-5-hydroxybenzoate

Base Information

• Chemical Name: ethyl 2-fluoro-5-hydroxybenzoate
• CAS No.: 1214387-36-6
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.167
• Hs Code.: 2918290090
• Mol file: 1214387-36-6.mol

Synonyms:C₉H₉FO₃

Chemical Property of ethyl 2-fluoro-5-hydroxybenzoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-fluoro-5-hydroxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-fluoro-5-hydroxybenzoate

There total 2 articles about ethyl 2-fluoro-5-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 2-fluoro-5-hydroxybenzoic acid (51446-30-1) → C9H9FO3 (1214387-36-6)

Guidance literature:

With sulfuric acid; at 80 ℃;

Reference yield:

→ C9H9FO3 (1214387-36-6)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield:

C9H9FO3 (1214387-36-6) → tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate (1307255-03-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling with ice

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; toluene; mineral oil;

upstream raw materials:

ethanol

2-fluoro-5-hydroxybenzoic acid

Downstream raw materials:

tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

C₁₉H₂₆FNO₄

Refernces

• 1、 -. "4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes". Paragraph 0565-0568; 0573-0576. . Retrieved 2014/03/21.