5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine

Base Information

• Chemical Name: 5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine
• CAS No.: 132631-87-9
• Molecular Formula: C₁₂H₇F₈N₃
• Molecular Weight: 345.195
• Mol file: 132631-87-9.mol

Synonyms:5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine

Chemical Property of 5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine

There total 6 articles about 5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-phenyl-3-pentafluoroethyl-4-trifluoromethyl-5-fluoropyrazole (121807-33-8) → 5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine (132631-87-9)

Guidance literature:

With ammonia; triethylamine; In 1,2-dimethoxyethane; at 90 ℃; for 10h;

DOI:10.1007/BF00958848

Reference yield:

phenylhydrazine (100-63-0) → 5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine (132631-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N / acetonitrile / 1 h / 20 °C

2: 71 percent / NH₃, Et₃N / 1,2-dimethoxy-ethane / 10 h / 90 °C

With ammonia; triethylamine; In 1,2-dimethoxyethane; acetonitrile;

DOI:10.1007/BF00958848

Reference yield:

2-(Trifluoromethyl)-1,1,1,4,4,5,5,5-octafluoropentan-3-one (61637-91-0) → 5-Pentafluoroethyl-2-phenyl-4-trifluoromethyl-2H-pyrazol-3-ylamine (132631-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / Et₃N / diethyl ether / 12 h / 20 °C

2: 71 percent / NH₃, Et₃N / 1,2-dimethoxy-ethane / 10 h / 90 °C

With ammonia; triethylamine; In 1,2-dimethoxyethane; diethyl ether;

DOI:10.1007/BF00958848

upstream raw materials:

1-phenyl-3-pentafluoroethyl-4-trifluoromethyl-5-fluoropyrazole

perfluoro-2-methylpent-2-ene

2-(Trifluoromethyl)-1,1,1,4,4,5,5,5-octafluoropentan-3-one

triethylammonium perfluoro-2-methyl-1-ethyl-1-propepenolate