2-Bromo-1,1-difluorocyclopropane

Base Information

• Chemical Name: 2-Bromo-1,1-difluorocyclopropane
• CAS No.: 51326-64-8
• Molecular Formula: C₃H₃BrF₂
• Molecular Weight: 156.958
• Hs Code.: 2902190000
• European Community (EC) Number: 815-195-5
• Mol file: 51326-64-8.mol

Synonyms:2-bromo-1,1-difluorocyclopropane;51326-64-8;2-Bromo-1,1-difluoro-cyclopropane;SCHEMBL11879907;UOMKSEBQTJOQJN-UHFFFAOYSA-N;BCA32664;MFCD20622605;AKOS037644390;PB42954;AS-53016;P15979;A857186

Chemical Property of 2-Bromo-1,1-difluorocyclopropane

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 155.93862
• Heavy Atom Count: 6
• Complexity: 71.2

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-1,1-difluorocyclopropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(C1(F)F)Br

Technology Process of 2-Bromo-1,1-difluorocyclopropane

There total 2 articles about 2-Bromo-1,1-difluorocyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

Vinyl bromide (593-60-2,25951-54-6) + 1,1,2,2,3,3-Hexafluoro-cyclopropane (931-91-9) → bromodifluoromethane (1511-62-2) + 1,1-difluoro-3-bromo-1-propene (60917-29-5) + 3-bromo-1,1,2,2-tetrafluorocyclobutane (374-29-8) + 2-bromo-1,1-difluorocyclopropane (51326-64-8)

Guidance literature:

at 290 ℃; for 0.5h; Further byproducts given. Yields of byproduct given; sealed tube in vacuo;

DOI:10.1016/S0022-1139(00)85225-2

Reference yield: 37.0%

Hexafluoropropene oxide (428-59-1,25038-02-2) + allyl bromide (106-95-6) → trifluoroacetyl fluoride (354-34-7) + 2-bromo-1,1-difluorocyclopropane (51326-64-8)

Guidance literature:

at 190 ℃; Sealed tube;

DOI:10.1021/ja3121058

Reference yield: 57.3%

2-bromo-1,1-difluorocyclopropane (51326-64-8) + methyl 2-chloro-4-(1-methyl-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoate → methyl 2-chloro-4-[[5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃;

upstream raw materials:

Vinyl bromide

1,1,2,2,3,3-Hexafluoro-cyclopropane

Hexafluoropropene oxide

allyl bromide