(+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate

Base Information

• Chemical Name: (+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate
• CAS No.: 131933-65-8
• Molecular Formula: C₃₅H₅₆NO₆P
• Molecular Weight: 617.807
• Mol file: 131933-65-8.mol

Synonyms:(+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate

Chemical Property of (+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate

There total 1 articles about (+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.1%

(+/-)-3-octadecanamido-2-ethoxy-1-propanol (112988-98-4) + chlorophosphoric acid diphenyl ester (2524-64-3) → (+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate (131933-65-8)

Guidance literature:

With pyridine; In diethyl ether; at 52 ℃; for 3h;

DOI:10.1021/jm00108a025

Reference yield: 93.3%

(+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate (131933-65-8) → (+/-)-3-octadecanamido-2-ethoxypropyl phosphate (131933-66-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; for 1.66667h; under 749.9 Torr; Ambient temperature;

DOI:10.1021/jm00108a025

Reference yield:

(+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate (131933-65-8) → 3'-azido-3'-deoxy-5'-(3-octadecanamido-2-ethoxypropyl)phosphothymidine (131933-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93.3 percent / H₂ / PtO₂ / ethanol / 1.67 h / 749.9 Torr / Ambient temperature

2: 26 percent / DDC / 96 h

With hydrogen; 2`,3`-dideoxycytidine; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm00108a025

upstream raw materials:

(+/-)-3-octadecanamido-2-ethoxy-1-propanol

chlorophosphoric acid diphenyl ester

Downstream raw materials:

(+/-)-3-octadecanamido-2-ethoxypropyl phosphate

3'-azido-3'-deoxy-5'-(3-octadecanamido-2-ethoxypropyl)phosphothymidine

Refernces