CP 92

Base Information

• Chemical Name: CP 92
• CAS No.: 131933-67-0
• Molecular Formula: C₃₃H₅₈N₆O₉P*Na
• Molecular Weight: 736.822
• Mol file: 131933-67-0.mol

Synonyms:CP 92

Chemical Property of CP 92

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 220.57000
• Density: g/cm³
• LogP: 7.00966

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CP 92

There total 3 articles about CP 92 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + (+/-)-3-octadecanamido-2-ethoxypropyl phosphate (131933-66-9) → 3'-azido-3'-deoxy-5'-(3-octadecanamido-2-ethoxypropyl)phosphothymidine (131933-67-0)

Guidance literature:

With 2`,3`-dideoxycytidine; for 96h;

DOI:10.1021/jm00108a025

Reference yield:

(+/-)-3-octadecanamido-2-ethoxy-1-propanol (112988-98-4) → 3'-azido-3'-deoxy-5'-(3-octadecanamido-2-ethoxypropyl)phosphothymidine (131933-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 60.1 percent / pyridine / diethyl ether / 3 h / 52 °C

2: 93.3 percent / H₂ / PtO₂ / ethanol / 1.67 h / 749.9 Torr / Ambient temperature

3: 26 percent / DDC / 96 h

With pyridine; hydrogen; 2`,3`-dideoxycytidine; platinum(IV) oxide; In diethyl ether; ethanol;

DOI:10.1021/jm00108a025

Reference yield:

(+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate (131933-65-8) → 3'-azido-3'-deoxy-5'-(3-octadecanamido-2-ethoxypropyl)phosphothymidine (131933-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93.3 percent / H₂ / PtO₂ / ethanol / 1.67 h / 749.9 Torr / Ambient temperature

2: 26 percent / DDC / 96 h

With hydrogen; 2`,3`-dideoxycytidine; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm00108a025

upstream raw materials:

3'-azido-2',3'-deoxythymidine

(+/-)-3-octadecanamido-2-ethoxypropyl phosphate

(+/-)-3-octadecanamido-2-ethoxy-1-propanol

(+/-)-3-octadecanamido-2-ethoxypropyl diphenyl phosphate

Refernces