(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Base Information

Chemical Name:(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol
CAS No.:1599531-32-4
Molecular Formula:C₃₄H₃₁ClF₃N₇O
Molecular Weight:646.115
Hs Code.:

Synonyms:(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

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Chemical Property of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

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Technology Process of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

There total 8 articles about (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599524-55-6
(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone

: 1599529-48-2
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-N,N-diethylquinolin-2-amine

: 1599531-32-4
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: (1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone; 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-N,N-diethylquinolin-2-amine; In tetrahydrofuran; for 0.166667h; Inert atmosphere; Cooling with acetone-dry ice;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; Inert atmosphere;

Reference yield:

: 99662-34-7
4-(1H-pyrazol-1-yl)benzaldehyde

: 1599531-32-4
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: L-proline / ethanol / 0.67 h

2.1: sodium hydroxide; water / 48 h / 110 °C

3.1: trichlorophosphate / 3 h / 105 °C

4.1: N,N-dimethyl-formamide / 23 h / 115 °C / Sealed tube

5.1: tetrahydrofuran / 0.17 h / Inert atmosphere; Cooling with acetone-dry ice

5.2: 1 h / -78 °C / Inert atmosphere

5.3: Inert atmosphere

With water; L-proline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1599528-96-7
5-(4-(1H-pyrazol-1-yl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1599531-32-4
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / 48 h / 110 °C

2.1: trichlorophosphate / 3 h / 105 °C

3.1: N,N-dimethyl-formamide / 23 h / 115 °C / Sealed tube

4.1: tetrahydrofuran / 0.17 h / Inert atmosphere; Cooling with acetone-dry ice

4.2: 1 h / -78 °C / Inert atmosphere

4.3: Inert atmosphere

With water; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;