3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

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Chemical Name:3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile
CAS No.:1599531-31-3
Molecular Formula:C₃₅H₃₁F₃N₈O
Molecular Weight:636.679
Hs Code.:

3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

Synonyms:3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

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Chemical Property of 3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

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Technology Process of 3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

There total 10 articles about 3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1599531-32-4
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(diethylamino)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

: 1599531-31-3
3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos; In N,N-dimethyl acetamide; at 120 ℃; for 4.08h; Inert atmosphere;

Reference yield:

: 99662-34-7
4-(1H-pyrazol-1-yl)benzaldehyde

: 1599531-31-3
3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: L-proline / ethanol / 0.67 h

2.1: sodium hydroxide; water / 48 h / 110 °C

3.1: trichlorophosphate / 3 h / 105 °C

4.1: N,N-dimethyl-formamide / 23 h / 115 °C / Sealed tube

5.1: tetrahydrofuran / 0.17 h / Inert atmosphere; Cooling with acetone-dry ice

5.2: 1 h / -78 °C / Inert atmosphere

5.3: Inert atmosphere

6.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc / N,N-dimethyl acetamide / 4.08 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; water; L-proline; sodium hydroxide; XPhos; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1599528-96-7
5-(4-(1H-pyrazol-1-yl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1599531-31-3
3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / 48 h / 110 °C

2.1: trichlorophosphate / 3 h / 105 °C

3.1: N,N-dimethyl-formamide / 23 h / 115 °C / Sealed tube

4.1: tetrahydrofuran / 0.17 h / Inert atmosphere; Cooling with acetone-dry ice

4.2: 1 h / -78 °C / Inert atmosphere

4.3: Inert atmosphere

5.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc / N,N-dimethyl acetamide / 4.08 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; water; sodium hydroxide; XPhos; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;