cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide

Base Information

Chemical Name:cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide
CAS No.:946001-13-4
Molecular Formula:C₁₅H₁₉ClN₂O
Molecular Weight:278.782
Hs Code.:

Synonyms:cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide

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Chemical Property of cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide

Chemical Property:

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Technology Process of cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide

There total 8 articles about cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 946001-10-1
cyclopropanecarboxylic acid 4-chloro-3-formyl-benzylamide

: 765-30-0
Cyclopropylamine

: 946001-13-4
cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide

Guidance literature:: cyclopropanecarboxylic acid 4-chloro-3-formyl-benzylamide; Cyclopropylamine; In methanol;

With sodium tetrahydroborate; In methanol; for 3h;

With sodium hydroxide; water; In methanol;

Reference yield:

: 873782-26-4
((5-bromo-2-chlorobenzyl)oxy)(tert-butyl)dimethylsilane

: 946001-13-4
cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium hydrogencarbonate / acetonitrile / 0.08 h

2.2: 0.17 h

3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

3.2: 3 h

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C

5.1: sodium hydroxide / methanol; water / 0.5 h / 80 °C

6.1: manganese(IV) oxide / acetonitrile / 5.5 h / 20 °C

7.1: methanol

7.2: 3 h

With manganese(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; acetonitrile;

Reference yield:

: 946000-08-4
3-(((tert-butyldimethylsilyl)oxy)methyl)-4-chlorobenzaldehyde

: 946001-13-4
cyclopropanecarboxylic acid 4-chloro-3-cyclopropylaminomethyl-benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / acetonitrile / 0.08 h

1.2: 0.17 h

2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

2.2: 3 h

3.1: triethylamine / dichloromethane / 0.5 h / 20 °C

4.1: sodium hydroxide / methanol; water / 0.5 h / 80 °C

5.1: manganese(IV) oxide / acetonitrile / 5.5 h / 20 °C

6.1: methanol

6.2: 3 h

With manganese(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; sodium hydrogencarbonate; triethylamine; In methanol; diethyl ether; dichloromethane; water; acetonitrile;